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KMID : 1101720160200010049
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Physical Activity and Nutrition
2016 Volume.20 No. 1 p.49 ~ p.64
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Hepatoprotective effects of hoveniae semen cum fructus extracts in ethanol intoxicated mice
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Cho Il-Je
Kim Joo-Wan
Jung Jai-Jun
Sung Soo-Hyun
Kim Jong-Kyu
Lee Nam-Ju
Ku Saek-Wang
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Abstract
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[Purpose] The objective of this study was to evaluate the hepatoprotective effects of Hoveniae Semen Cum Fructus extract in ethanol induced hepatic damages.
[Methods] Hepatic damages were induced by oral administration of ethanol and then Hoveniae Semen Cum Fructus extract was administered.
[Results] Following Hoveniae Semen Cum Fructus extract administration, body and liver weights were increased, while aspartate aminotransferase, alanine aminotransferase, albumin, γ-glutamyl transferase, and triglyceride levels in the serum, triglyceride contents, tumor necrosis factor -α level, cytochrome (CY) P450 2E1 activity in the liver and mRNA expression of hepatic lipogenic genes, and Nitrotyrosine and 4-HNE-immunolabelled hepatocytes were decreased. However, mRNA expression of genes involved in fatty acid oxidation was increased. Also, as a protective mechanism for hepatic antioxidant defense systems, decreased liver MDA contents, increased glutathione contents, increased dismutase and catalase activities were observed when compared to the ethanol control.
[Conclusion] Hoveniae Semen Cum Fructus extract favorably protected against liver damages, mediated by its potent anti-inflammatory and anti-steatosis properties through the augmentation of the hepatic antioxidant defense system by NF-E2-related factor-2 activation, and down-regulation of the mRNA expression of hepatic lipogenic genes or up-regulation of the mRNA expression of genes involved in fatty acid oxidation.
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KEYWORD
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Hoveniae, hepatoprotective, mouse, Nrf2, antioxidant
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